The location of the casino is important when choosing one to visit. Golden Nugget Biloxi Hotel & Casino in Biloxi has no doubt some of the best slot machines. What is the Casino with the loosest slots machines in Biloxi? Each casino has its own unique atmosphere and games. Mississippi has several casinos that draw in huge crowds of people on a daily basis. In fact, many casinos are located on the coast so people can enjoy their entertainment and games without traveling far. Gambling is a leisure activity that some people consider an art.